Analysis on Distribution and Drug Resistance of Acinetobacter baumannii in Our Hospital during 2012-2015
10.6039/j.issn.1001-0408.2016.26.07
- VernacularTitle:我院2012－2015年鲍曼不动杆菌分布及耐药性分析
- Author:
Yajian HUANG
;
Jiawei CHEN
;
Xuguang GUO
;
Bing SITU
- Publication Type:Journal Article
- Keywords:
Acinetobacter baumannii;
Distribution;
Multidrug-resistant;
Pandrug-resistant;
Antibiotics;
Drug resistance
- From:
China Pharmacy
2016;27(26):3624-3626,3627
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the distribution and drug resistance of Acinetobacter baumannii in our hospital,and provide reference for rational use of antibiotics. METHODS:Clinical specimen of inpatients in our hospital from Jan. 2012 to Dec. 2015 was collected,the identification of strains and drug sensitivity test were performed by the VITEK-2 microorganism analyzer;use rate of antibiotics and detection of multidrug-resistant and pandrug-resistant A. baumannii for inpatients in our hospital were an-alyzed,and their correlation was detected by Pearson correlation analysis. RESULTS:Totally 2 468 strains of A. baumannii were isolated in our hospital during 2012-2015,mainly derived from sputum samples (88.2%),distributed in respiratory medicine de-partment(47.0%)and ICU(13.1%);A. baumannii showed totally high drug resistance to common antibiotics,and only sensitive to tigecycline. Totally 386(79.3%),434(61.6%),358(53.4%)and 291(48.0%)strains multidrug-resistant A. baumannii were detected every year in our hospital;and pandrug-resistant A. baumannii were 336(69.0%),385(54.7%),331(49.3%)and 256 (42.2%) strains,respectively. There was a positive correlation between the percentage of multidrug-resistant and pandrug-resistant A. baumannii in total strains and use rate of antibiotics (r=0.987、0.981,P<0.05). CONCLUSIONS:A. baumannii has emerged as an important pathogen in hospital acquired infections,which mainly caused respiratory system infection;the drug resistance situ-ation is not optimistic,tigecycline can be used as one of the best choice for treatment of A. baumannii infections;our hospital should continue to control the use of antibiotics to decrease the emerging of drug resistance strains.
