Protection Effects of Metformin Combined with Calcitriol on Renal Function and Retina in Patients with Type 2 Diabetes
10.6039/j.issn.1001-0408.2016.30.17
- VernacularTitle:二甲双胍联合骨化三醇对2型糖尿病患者肾功能及视网膜的保护作用
- Author:
Wenju WANG
;
Yunlong KONG
- Publication Type:Journal Article
- Keywords:
Metformin;
Calcitriol;
Diabetic nephropathy;
Retinopathy
- From:
China Pharmacy
2016;27(30):4227-4229,4230
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the protection effects of Metformin combined with Calcitriol on renal functiou and retina in patients with type 2 diabetes. METHODS:80 patients with type 2 diabetes with early diabetic nephropathy and mild-to-moderate non proliferative retinopathy were randomly divided into control group(40 cases)and observation group(40 cases). Control group received Metformin hydrochloride tablet with initial dose of 0.5 g,twice a day during a meal,increased 0.5 g every week,then gradually increased to 2 g every day;observation group additionally received Calcitriol soft capsule,0.25 μg/times,once a day. The treatment lasted and followed-up for 6 months. Efficacy of retinopathy,blood glucose levels [2 h postprandial blood glucose (2 h PG),blood glucose (FPG)],renal function indexes [urinary albumin-to-creatinine ratio (ACR),urinary albumin excretion rate (UAER),proteinuria (Pr)],vision and visual field defects,fundus angiography before and after treatment,and the incidence of adverse reactions in 2 groups were observed. RESULTS:The total effective rate in observation group was significantly higher than in control group,and the difference was statistically significant(P<0.05). Before treatment,there were no significant differences in the 2 h PG,FPG,ACR,UAER,Pr,vision and visual field defects between 2 groups (P>0.05). After treatment,2 h PG, FPG were significantly lower than before;ACR,Pr,UAER,average value of visual field defects,fundus angiography and bleed-ing area were significantly lower than before,and observation group was lower than control group;vision was significantly higher than before,and observation group was higher than control group. The differences were statistically significant (P<0.05). There was respectively 1 patient showed slight adverse reactions in both groups. CONCLUSIONS:Metformin combined with Calcitriol has certain protection effect on the renal function and retina in patients with type 2 diabetes,it can reduce 2 h PG,FPG,ACR, Pr,UAER,average value of visual field defects,fundus angiography and bleeding area of patients and improve vision,with small adverse reactions and high safety.
