Systematic Review of Efficacy of Tibolone Tablet in the Treatment of Senile Vaginitis
10.6039/j.issn.1001-0408.2016.30.23
- VernacularTitle:替勃龙片治疗老年性阴道炎疗效的系统评价
- Author:
Jing TU
;
Shiying ZHANG
- Publication Type:Journal Article
- Keywords:
Tibolone tablet;
Senile vaginitis;
Clinical efficacy;
Meta-analysis
- From:
China Pharmacy
2016;27(30):4249-4251,4252
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To systematically review the clinical efficacy of Tibolone tablet in the treatment of senile vaginitis, and provide evidence-based reference for clinical treatment. METHODS:Retrieved from PubMed,Medline,CJFD,CBM,VIP and Wangfang Database,randomized controlled trials(RCT)about Tibolone tablet in the treatment of senile vaginitis were collct-ed. Meta-analysis was performed by using Rev Man 5.2 software after data extract and quality evaluation. RESULTS:Totally 10 RCTs were enrolled,involving 909 patients. Results of Meta-analysis showed Tibolone tablet can significantly improve the cure rate of senile vaginitis [RR=1.46,95%CI(1.32,1.61),P<0.001],maturation vaginal cell index score [SMD=1.83,95%CI(1.65, 2.01),P<0.001] and vaginal health score [SMD=1.56,95%CI(1.21,1.92),P<0.001],reduce recurrence rate [RR=0.07,95%CI (0.02,0.18),P<0.001] and vaginitis score [SMD=-1.44,95%CI(-1.79,-1.08),P<0.001]. CONCLUSIONS:Tibolone tablet has good clinical efficacy in the treatment of senile vaginitis,it can improve the vaginal mucosa estrogen and vaginal environment, reduce recurrence rate.
