Diffusion tensor imaging for brain damage of acute CO intoxication
10.3969/j.issn.1002-1671.2016.10.001
- VernacularTitle:急性一氧化碳中毒脑损伤的磁共振扩散张量成像
- Author:
Yanan ZHU
;
Hao YAN
;
Jun YAO
;
Peng YE
;
Yukun LIANG
;
Yang XIANG
;
Dingping CAI
;
Zhengjun LI
;
Heping ZHOU
- Publication Type:Journal Article
- Keywords:
carbon monoxide;
intoxication;
cerebropathy;
diffusion tensor imaging;
magnetic resonance imaging
- From:
Journal of Practical Radiology
2016;32(10):1489-1493,1501
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate altered microstructural integrity in acute carbon monoxide(CO)intoxication by diffusion tensor imaging (DTI).Methods A total of 25 CO intoxication patients (5.0±1.44 post-intoxication)and 37 healthy volunteers matched with age, sex and educational level were involved and underwent DTI.The fractional anisotropy (FA)and apparent diffusion confficient (ADC) of total 26 regions of bilateral cerebellum,substantia nigra,hippocampus,white matter of frontal lobe,head of caudate nucleus,pallidum,thalamus, anterior limb of internal capsule,posterior limb of internal capsule,white matter of occipital lobe,white matter of parietal lobe,and genu of corpus callosum,splenium of corpus callosum were measured.Compared the patients against control for FA and ADC by paired t-test.Results FA of patients with CO intoxication decreased in bilateral pallidum,anterior limb of internal capsule,substantia nigra,right cerebellum,left below frontal white matter,right frontal white matter and genu of corpus callosum (P <0.05).ADC decreased in right substantia nigra,and left pallidum (P <0.05).ADC increased in right frontal white matter and bilateral occipital lobe white matter (P<0.05).Conclusion There is loss of microstructural integrity in acute CO intoxication,perhaps representing the underlying mechanism of delayed encephalopathy after carbon monoxide poisoning.
