Study on the relationship between polymorphism site rs13146124 of IRF2 and systemic lupus erythematosus patients﹡
10.3969/j.issn.1671-8348.2016.30.017
- VernacularTitle:IRF2基因 rs13146124位点多态性与系统性红斑狼疮的关联性研究
- Author:
Xiaoli CUI
;
Hongmei LI
;
Shuihe LIU
;
Zhenxuan YE
;
Hua ZHANG
- Publication Type:Journal Article
- Keywords:
systemic lupus erythematosus;
interferon regulatory factor;
gene polymorphism
- From:
Chongqing Medicine
2016;45(30):4230-4232,4236
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between single nucleotide polymorphism rs13146124 of interferon regu‐latory factor2(IRF2) on type Ⅰ interferon pathway and systemic lupus erythematosus(SLE) in a population from Guizhou Prov‐ince .Methods The polymorphism IRF2(rs13146124) was detected by using Taqman‐PCR in 366 cases of patients with SLE and 218 healthy controls .The genotype and allele frequencies were calculated and analyzed .Results The genotype frequencies of AA , AG and GG in IRF2 rs13142164 site in patients with SLE were 0 .011 ,0 .246 and 0 .743 respectively ,compared with the control group ,the difference was not statistically significant (χ2 =0 .093 ,0 .205 ,0 .136 ;P=0 .761 ,0 .651 ,0 .712) .The allele frequencies of A and G in IRF2 rs13146124 site in SLE patients were 0 .13 ,0 .87 respectively ,compared with the control group ,the difference was not statistically significant(χ2 =0 .071 ,P=0 .790) .There was no significant difference between the allele frequencies of A and G in IRF2 rs13146124 site in SLE and ANA ,dsDNA and other specific antibodies .There was no correlation between the allele frequen‐cies of A and G in IRF2 rs13146124 site in SLE and clinical features such as arthritis ,kidney damage ,etc .Conclusion The poly‐morphism of rs13146124 in IRF2 may not be associated with SLE in the population from Guizhou Province .
