Effects of Erythropoietin on Nerve Function and Brainstem Auditory Evoked Potential in the Preterm Chil-dren with Brain Damage
10.6039/j.issn.1001-0408.2016.29.18
- VernacularTitle:促红细胞生成素对脑损伤早产儿神经功能及脑干听觉诱发电位的影响
- Author:
Yu WANG
;
Dongming SUN
;
Jinglu JI
;
Jinxiu BAI
;
Xiaowei YANG
;
Chen LI
;
Na AN
- Publication Type:Journal Article
- Keywords:
Preterm children;
Erythropoietin;
Brain injury;
Brainstem auditory evoked potential;
Nerve cell
- From:
China Pharmacy
2016;27(29):4091-4092,4093
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effects and safety of erythropoietin on nerve function and brainstem auditory evoked potential in the preterm children with brain damage. METHODS:46 preterm children with brain damage were randomly di-vided into treatment group and control group,with 23 cases in each group. Control group received conventional symptomatic treat-ment as respiratory support,nutritional support,vitamin K supplement and ganglioside. Treatment group was additionally given rhE-PO for injection (CHO cell) 500 IU/kg hypodermically,3 times a week,on the basis of control group. Both group received 3-4 weeks of treatment continuously. MDI,PDI,the content of serum nerve injury factor(NSE,S-100β),latent period and peak inter-val of brainstem auditory evoked potential were compared between 2 groups before and after treatment,and the occurrence of ADR was observed in 2 groups. RESULTS:There was no statistical significance in MDI,PDI,the content of serum nerve injury mole-cule,latent period and peak interval of brainstem auditory evoked potential between 2 groups before treatment (P>0.05). After treatment,MDI and PDI of 2 groups increased significantly,while the content of serum nerve injury factor,latent period and peak interval of brainstem auditory evoked potential decreased significantly;the treatment group was better than the control group,with statistical significance (P<0.05). No obvious ADR was found in 2 groups. CONCLUSIONS:Erythropoietin can significantly im-prove intelligence development,protect the damaged nerve cells and auditory nerve pathways with good safety.