The study on short-time therapeutic effect and adverse reaction observation of TOMOX regimen combined with three dimensional conformal radiotherapy for middle and advanced esophageal cancer
10.3969/J.ISSN.1672-8270.2016.10.018
- VernacularTitle:TOMOX方案联合三维适形放射治疗中晚期食管癌的近期疗效及不良反应观察
- Author:
Yihong ZHAO
;
Weidong XU
;
Fuli ZHANG
- Publication Type:Journal Article
- Keywords:
Three dimensional conformal;
TOMOX;
Radiotherapy;
Esophageal cancer
- From:
China Medical Equipment
2016;13(10):61-63,64
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the efficacy and adverse reaction of TOMOX regimen combined with three dimensional conformal radiotherapy in the treatment of middle and advanced esophageal cancer. Methods:51 cases of hospitalized patients with esophageal cancer were selected from January 2013 to December 2015 in our hospital who were divided into observation group (n=27) and control group (n=24) by random number table method. The control group was treated with three dimensional conformal radiotherapy, and the observation group was added with the TOMOX scheme based on the control group. Compare the efficacy of the two groups, the control period, the survival period, the toxicity and side effects.Results: The rate of complete response(CR)and partial response (PR) in the observation group was significantly higher than that in the control group, the difference was statistically significant (P<0.05). The total effective rate of the observation group was 96.30%, which was significantly higher than that of the control group 58.33% (P<0.001). The 2 year control rate and 2 years survival rate of the observation group was significantly higher than that of the control group (P<0.05). The incidence of acute radiation pneumonia and gastrointestinal reaction in observation group was lower than the control group, the difference was statistically significant (P<0.05).The neuritis rate and leukopenia of observation group was lower than the control group, but the difference was not statistically significant (P>0.05). The rate of acute esophagitis in the observation group group was higher than that in the control group, the difference was statistically significant (P<0.05).Conclusion: TOMOX combined with three-dimensional conformal radiation therapy can effectively improve the short-term efficacy and long-term survival rate, reduce adverse reactions.
