Expression of Human Epidermal Growth Factor Receptor 2 and Correlation with Clinical Pathological Features in Breast Cancer
10.3969/j.issn.1671-7414.2016.05.024
- VernacularTitle:人类表皮生长因子受体2在乳腺癌表达与临床的相关病理特征分析
- Author:
Yanmei LIU
;
Shaojun MA
;
Yuelang ZHANG
;
Xiaoli KANG
;
Xiaoyan LIANG
;
Liqian ZHOU
;
Wensheng LI
- Publication Type:Journal Article
- Keywords:
breast cancer;
human epidermal growth factor receptor 2;
clinical pathological features
- From:
Journal of Modern Laboratory Medicine
2016;31(5):91-93,96
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate of value of HER2 as a prognostic marker,and to analysis associations with common his-topathological parameters in BC cases.Methods In this study,formalin-fixed,paraffin-embedded samples of tumors from 160 breast cancer patients who underwent curative surgery proce-dures between 2011 and 2014 were tested by immunohisto-chemistry (IHC)as aprimary estimate of HER2 status,followed by fluorescence in situ hybridization (FISH).Concordance rate between IHC and FISH was evaluated.Theχ2 test was used to evaluate the correlation between HER2 gene amplifica-tion status and different clinical pathological features including:(estrogen receptor)ER and (progesterone receptor)PR ex-pression,age,menopausal status and tumor size.Results There was a significant inverse association between expression of hormone receptors (ER and PR)and HER2 amplification (all P<0.05)among the patients studied.However,no relation-ship was observed between HER2 amplification and age,menopausal status and tumor size (P>0.05).HER2-negative le-sions were of higher grade and more likely to be ER-negative,PR-negative,p5 3-positive,lymph node metastasis,and also Ki-67≥20% as compared to the HER2-positive group and HER2 overe xpression was associated with the levels of ER and PR. Conclusion There is correlation of many clinical factors with HER2 expression.
