The protein expression and activity of glycogen synthase kinase 3βin the peripheral blood mononuclear cells of type 2 diabetic patients
10.3969/j.issn.1673-4130.2016.20.011
- VernacularTitle:2型糖尿病患者糖原合成酶激酶3β的表达及活性
- Author:
Jie TAN
;
Jianhua WU
;
Jiangping WANG
;
Junqing ZOU
;
Anping MING
- Publication Type:Journal Article
- Keywords:
type 2 diabetes mellitus;
peripheral blood mononuclear cells;
glycogen synthase kinase 3β
- From:
International Journal of Laboratory Medicine
2016;37(20):2831-2832,2835
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical value of observing the differences of GSK‐3βprotein expression and activity lev‐el in the peripheral blood mononuclear cells between type 2 diabetes mellitus patients and healthy people .Methods Using ELISA to detect the GSK‐3βprotein expression and activity levels of people who contained 30 patients with type 2 diabetes whose blood glu‐cose were not controlled (test group 1) ,30 cases of patients with type 2 diabetes whose blood glucose were controlled (test group 2) and 30 cases of healthy human and all the data were analyzed .Results The GSK‐3βprotein content of Type 2 diabetes mellitus group was higher than the control group(P<0 .05) ,the activity level of GSK‐3βin test group 1 was higher than the control group and test group(P<0 .05) .The GSK‐3β protein content of test group 2 was higher than the control group(P< 0 .05) .The male GSK‐3βactivity level in the test group 1 was higher than the men′s in the control group(P<0 .05) .Conclusion The GSK‐3βprotein content has a high expression in the type 2 diabetes mellitus patients .After drug treatment ,the patients ,who have controlled the blood glu‐cose effectively ,still showes high expression of the GSK‐3βprotein content ,but the activity levels showes a significant decline .In male pa‐tients with type 2 diabetes blood sugar in the control group of GSK‐3βshowes significantly higher activity level .
