Efficacy Observation of Clomiphene Combined with Metformin in the Treatment of Polycystic Ovary Syn-drome
10.6039/j.issn.1001-0408.2015.29.37
- VernacularTitle:克罗米芬联合二甲双胍治疗多囊卵巢综合征的疗效观察
- Author:
Yali YU
- Publication Type:Journal Article
- Keywords:
Clomiphene;
Metformin;
Polycystic ovarian syndrome;
Clinical efficacy
- From:
China Pharmacy
2015;(29):4138-4139,4140
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe clinical efficacy of clomiphene combined with metformin in the treatment of polycys-tic ovary syndrome. METHODS:112 patients with polycystic ovary syndrome admitted in gynaecology and obstetrics depart-ment of our hospital were selected,and randomly divided into control group and observation group,with 56 cases in each group. Control group was treated with clomiphene orally,since fifth day of menstruation,once a day,50 mg/time;observa-tion group was additionally treated with metformin orally,30 min before meal,3 times a day,500 mg/d. Treatment course last-ed for 2 months. Biochemical indicators,control time of disease,actual treatment time,HOMA-IR,HOMA-β and clinical effi-cacy of patients were observed in two groups. RESULTS:After treatment,LH,FSH,T and FINS of patients in observation group were lower than before treatment and control group,with statistical significance(P<0.05);control time of disease and actual treatment time of observation group were significantly shorter control group (P<0.05),with statistical significance;HOMA-IR and HOMA-β of observation group were significantly lower than those of control group,with statistical significance (P<0.05);clinical effective rate of patients in observation group was significantly higher than control group,with statistical significance (P<0.05). CONCLUSIONS:Clomiphene combined with metformin in the treatment of polycystic ovarian syn-drome can improve biochemical indicators,shorten control time of disease and actual treatment time and enhance clinical effi-cacy.
