Clinical Observation of Lisinopril Combined with Losartan Potassium in the Treatment of Chronic Heart Fail-ure
10.6039/j.issn.1001-0408.2015.27.08
- VernacularTitle:赖诺普利联合氯沙坦钾治疗慢性心力衰竭的临床观察
- Author:
Xia LI
;
Huailan LI
- Publication Type:Journal Article
- Keywords:
Lisinopril;
Losartan potassium;
Chronic heart failure;
Efficacy;
Safety
- From:
China Pharmacy
2015;(27):3767-3768,3769
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the efficacy and safety of lisinopril combined with losartan potassium in the treatment of chronic heart failure (CHF). METHODS:72 patients with CHF were randomly divided into observation group and control group. All patients were given salt restriction,diuretics and other conventional treatment. Based on the treatment,control group was orally treated with lisinopril tablets 10 mg,once a day,the dose was increased to 2 times after 1-2 weeks until the maximum dose of 40 mg,orally,once a day. Based on the treatment of control group,observation group was additionally treated with losartan potassi-um tablets 50 mg,orally,once a day. The efficacy was evaluated,and cardiothoracic ratio,LVEDD,LVESD,LVEF,HR,SBP,DBP and incidence of adverse reactions were observed after 2 months treatment. RESULTS:The total effective rate in observation group was significantly higher than control group(P<0.05). After treatment,cardiothoracic ratio,LVEDD,LVESD,HR,SBP and DBP in 2 groups were significantly lower than before,and observation group was lower than control group,LVEF was significantly high-er than before,observation group was higher than control group,there was significant difference(P<0.05). There was no signifi-cant difference in the incidence of adverse reactions(P>0.05). CONCLUSIONS:Based on the coventional treatment,lisinopril com-bined with losartan potassium has better efficacy than lisinopril in the treatment of CHF,with good safety.
