Clinical Observation of Minocycline Hydrochloride Combined with Tinidazole in the Treatment of Chronic Periodontis
10.6039/j.issn.1001-0408.2015.27.15
- VernacularTitle:盐酸米诺环素联合替硝唑治疗慢性牙周炎的临床观察
- Author:
Yong LIU
;
Xuexia WANG
- Publication Type:Journal Article
- Keywords:
Minocycline hydrochloride;
Tinidazole;
Chronic periodontitis;
Efficacy;
Safety
- From:
China Pharmacy
2015;(27):3784-3785,3786
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the efficacy and safety of minocycline hydrochloride combined with tinidazole in the treat-ment of chronic periodontitis. METHODS:100 patients with chronic periodontitis were randomly divided into observation group 1, observation group 2,observation group 3 and control group. Patients in control group were given full-mouth dental scalers and sub-gingival clean scraping,then 0.9% Sodium chloride injection and 3% hydrogen peroxide were used to alternately wash periodontal pocket bottom. Based on the treatment,observation group 1 was injected Minocycline hydrochloride ointment to periodontal pocket bottom until slight overflow after saliva isolation and desiccation,once a week;observation group 2 was given Tinidazole buccal tablet 1 tablet in the buccal middle gingival surface,twice a day,observation group 3 was given Minocycline hydrochloride oint-ment+Tinidazole buccal tablets(the usage and dosage was the same with above-mentioned 2 groups). The treatment course was 4 weeks. The clinical efficacy,PLI,PAL,PPD,MD,GI before and after treatment and incidence of adverse reactions were observed. RESULTS:The total effective rate in observation group 3>observation group 1 and observation group 2>control group(P<0.05), however,there was no significant difference between observation group 1 and observation group 2(P>0.05). After treatment, PLI,PAL,PPD,MD and GI in all groups were significantly lower than before,and observation group 30.05). There were no obvious adverse reactions during treatment. CONCLUSIONS:Minocycline hy-drochloride combined with tinidazole has better efficacy than minocycline hydrochloride or tinidazole in the treatment of chronic periodontitis,with good safety.
