Effect of Folic Acid on the Homocysteine level and Flow-mediated Vasodilation and Cognitive Function in the Treatment of Elderly Patients with Cerebral Infarction
10.6039/j.issn.1001-0408.2015.27.17
- VernacularTitle:叶酸对老年脑梗死患者同型半胱氨酸水平和血管舒张功能及认知功能的影响
- Author:
Heting LUO
;
Jinpei ZHANG
;
Yi ZHANG
;
Yanchen WANG
;
Xiaojun LU
- Publication Type:Journal Article
- Keywords:
Folic acid;
Cerebral infarction;
Homocysteine;
Cognitive Function;
Flow-mediated vasodilation
- From:
China Pharmacy
2015;(27):3789-3790,3791
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To discuss the effect of folic acid on the homocysteine(Hcy)and flow-mediated vasodilation and cog-nitove function in the treatment of elderly patients with cerebral infarction. METHODS:The data of 198 elderly patients with cere-bral infarction was randomly divided into the observation group and the control group by different medication. Control group was treated with conventional treatment;based on the treatment of control group,observation group was orally treated with Folic acid tabelts 5 mg,once a day. The treatment course of 2 groups was 8 weeks. The Hcy level and flow-mediated vasodilation(FMD)be-fore and after treatment,mini-mental state examination (MMSE) score and incidence of adverse reactions in 2 groups were ob-served. RESULTS:After treatment,Hcy level in observation group was significantly lower than before and control group,FMD was significantly higher than before and control group(P<0.01). MMSE score in observation group was significantly higher than control group(P<0.01). There were no obvious adverse reactions in 2 groups during treatment. CONCLUSIONS:Based on the con-ventional treatment,folic acid can effectively reduce the Hcy level of elderly patients with cerebral infarction,improve the cogni-tive function and reduce the brain tissue damage,with good safety.
