Study on Bactericidal Activity of Thymopentin Peptide and Its Derived Peptides
10.6039/j.issn.1001-0408.2015.28.10
- VernacularTitle:胸腺五肽及其衍生肽的杀菌活性研究Δ
- Author:
Ting XIE
;
Tingting TAO
;
Ningsheng LIANG
- Publication Type:Journal Article
- Keywords:
Thymopentin;
Derived peptides;
Bactericidal activity;
Aspartic acid;
Agedoite;
Lysine
- From:
China Pharmacy
2015;(28):3918-3919,3920
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the bactericidal activity of thymopentin and its derived peptides. METHODS:Agar plate count was adopted to determine the bactericidal activity of thymopentin [arginine(R)-lysine(K)-aspartic acid(D)-valine(V)-tyro-sine(Y),RKDVY],its derived peptide 1 [RKN(agedoite,N)VY] and derived peptide 2(RKKVY)to Gram negative bacterial (Proteusbacillus vulgaris,Escherichia coli) and Gram positive bacterial (Staphylococcus aureus,Enterococcus faecium). There were 15.625-1 000 μg/ml for peptides,102 CFU for bacteria. RESULTS:Three pentapeptides possessed bactericidal activity against Gram negative bacteria. The activities of RKKVY and RKNVY were stronger than RKDVY(P<0.01),there was no significant dif-ference between RKKVY and RKNVY(P>0.05). They also possessed bactericidal activity against Gram positive bacteria,and the activity from strong to weak was RKKVY>RKNVY>RKDVY(P<0.01). CONCLUSIONS:Thymopentin and its derived peptides possess bactericidal activity against Gram negative and positive bacteria,with dose-effect relationship.