Pharmacokinetic Study of Puerain Solid Self-microemulsion Capsules in Rats in vivo
10.6039/j.issn.1001-0408.2015.34.07
- VernacularTitle:葛根素固体自微乳胶囊在大鼠体内的药动学研究
- Author:
Hongyan ZHANG
;
Hongsheng SUN
;
Jian LIU
;
Xiaoli SUI
;
Xiaoqian TIAN
- Publication Type:Journal Article
- Keywords:
Puerarin;
Solid self-microemulsion capsule;
Rat;
Pharmacokinetics;
Bioavailability
- From:
China Pharmacy
2015;(34):4773-4774,4775
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the pharmacokinetic characteristics of Puerarin solid self-microemulsion capsules in rats in vi-vo. METHODS:The rats were randomly divided into two groups with 18 rats in each group. They were given Puerarin solid self-mi-croemulsion capsules(S-SMEDDS capsules)and commercially available Yufeng ningxin tablet,with the dose of 158.15 mg/kg puer-arin. The 0.2 ml blood samples were collected from tail vein 0,5,10,20,40,60,90,120,180,240,360,480,600 min after medication,respectively. The blood concentration of puerarin was determined by HPLC,and pharmacokinetic parameters and rela-tive bioavailability were calculated by using 3p87 software. RESULTS:The metabolism of puerarin was one-compartment model in rats. Pharmacokinetic parameters of S-SMEDDS capsules and Yufeng ningxin tablet were as follows as cmax of (1.032 0 ± 0.020 6) and(0.587 3±0.011 7)μg/ml,t1/2ke of(116.431 4±2.166 0)and(88.222 6±1.752 4)min,AUC0-t of(261.532 2±1.464 0)and (102.835 5±1.957 4)μg·min/ml. Relative bioavailability was 238.77%. CONCLUSIONS:Compared with Yufeng ningxin tablet, S-SMEDDS capsules are absorbed more completely and removed faster.
