Medication Analysis of Therapeutic Drug Monitoring for Tacrolimus in Allogeneic Hematopoietic Stem Cell Transplantation

VernacularTitle:他克莫司血药浓度监测在异基因干细胞移植患者中的应用
Author: Hua OUYANG ; Ziyu HE ; Wanbin HUANG
Publication Type:Journal Article
Keywords: Tacrolimus; Allo-HSCT; Blood concentration monitoring; Analysis of drug use
From: China Pharmacy 2015;(26):3652-3654,3655
CountryChina
Language:Chinese
Abstract: OBJECTIVE:To investigate blood concentration monitoring data,therapeutic efficacy,toxic reaction and combi-nation of tacrolimus in patients with Allo-HSCT,and to provide reference for clinical application of tacrolimus. METHODS:The blood concentration of tacrolimus in 16 inpatients were monitored with EMIT 3 months after Allo-HSCT. The occurrence of Graft-versus-Host disease(GVHD),ADR and drug combination were analyzed and discussed. RESULTS:A large individual dif-ferences were found in blood concentration of tacrolimus. When blood concentration <8 ng/ml,there seems a greater possibility of GVHD. When >20 ng/ml,the occurrence of diabetes,kidney damage and other side effects seems increased. Tacrolimus had a good effect on treatment and prevention of GVHD,and could have an interaction with other drugs. CONCLUSIONS:Blood concentration monitoring of tacrolimus plays an important role on the prevention and treatment of GVHD,and the decrease of side effects such as diabetes and neurotoxicity. The satisfactory blood concentration is 8-20 ng/ml,when there seems a smaller possibility of GVHD and ADR 3 months after Allo-HSCT.