Clinical Observation of Bronchial Arterial Infusion Chemotherapy Combined with Cinobufacini Capsule in the Treatment of Advanced Non-small Cell Lung Cancer
10.6039/j.issn.1001-0408.2015.26.33
- VernacularTitle:支气管动脉灌注化疗联合华蟾素胶囊治疗晚期非小细胞肺癌的临床观察
- Author:
Wangang LI
;
Jing CUI
;
Jianjun WANG
;
Jiyun WANG
- Publication Type:Journal Article
- Keywords:
Bronchial arterial infusion;
Chemotherapy;
Taxotere;
Cinobufacini capsule;
Non-small cell lung cancer
- From:
China Pharmacy
2015;(26):3703-3705,3706
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe clinical efficacy and toxic reaction of bronchial artery infusion(BAI)chemotherapy com-bined with Cinobufacini capsule in the treatment of advanced non-small cell lung cancer(NSCLC). METHODS:A total of 126 cas-es of advanced NSCLC diagnosed in stage Ⅲb-Ⅳ were randomly divided into observation and control group,63 cases in each group. Both of them were treated by BAI with taxotere/cisplatin(TP regimen),once every three weeks for a cycle,a total of 5 cy-cles;observation group was additionally given Cinobufacini capsule 500 mg/time,three times a day,on the basis of BAI chemo-therapy,for 15 weeks. Clinical efficacy,KPS,survival rate and toxic reaction of 2 groups were observed. RESULTS:The total ef-fective rate(82.54%)of observation group was better than that(63.49%)of control group,with statistical significance(P<0.05). KPS score of observation group was significantly better than that of control group,with statistical significance (P<0.05). 1-year survival rate of observation group and control group were 65.08% and 30.15%,2-year survival rate of them were 19.05% and 4.76%,with statistical significance(P<0.05). Adverse reactions of two groups was mainly marrow suppression and gastrointesti-nal reaction,marrow suppression degree and the incidence of nausea and vomiting in observation group was lighter than control group,with statistical significance (P<0.05). CONCLUSIONS:BAI combined with Cinobufacini capsule in the treatment of ad-vanced NSCLC can improve short-term curative effect and long-term survival rate,and can improve the survival quality with little toxic effect.
