Preventive effect of salmeterol xinafoate and fluticasone propionate aerosol on radiation pneumonia in local advanced non-small cell lung cancer: a clinical study
10.3760/cma.j.issn.1006-9801.2016.08.007
- VernacularTitle:沙美特罗替卡松气雾剂预防局部晚期非小细胞肺癌放射性肺炎的临床研究
- Author:
Yingqiang JIANG
;
Hui ZHONG
;
Ming LI
;
Gaoping SONG
- Publication Type:Journal Article
- Keywords:
Salmeterol xinafoate and fluticasone propionate aerosol;
Radiotherapy,intensity-modulated;
Radiation pneumonitis;
Carcinoma,non-small-cell lung
- From:
Cancer Research and Clinic
2016;28(8):534-537,557
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the preventive effect of salmeterol xinafoate and fluticasone propionate aerosol on radiation pneumonia in patients with local advanced non-small cell lung cancer (NSCLC) after radiotherapy.Methods Sixty-four patients with local advanced NSCLC were randomly divided into the study group and the control group.Both groups were treated with intensity modulated radiation therapy treatment and routine interventions.Salmeterol xinafoate and fluticasone propionate aerosol were given to the study group from the first day of radiation therapy at both the morning and evening time.Clinical symptoms,chest CT,Karnofsky score and tumor necrosis factor-α (TNF-α) levels in the two groups were analyzed at the time before radiotherapy and three months after radiotherapy.Results The radiation pneumonia incidence of the study group was lower than that of the control group [21.9 ％(7/32) vs 46.9 ％(15/32)].The plasma TNF-α content after radiotherapy of the study group was lower than that of the control group [(9.18±3.45) ng/ml vs (13.38 ± 2.75) ng/ml].Moreover,the Karnofsky score of the study group was higher than that of the control group [(81.67 ± 7.18) scores vs (75.00+ 6.74) scores].The differences between the two groups were statistically significant (all P＜ 0.05).Conclusion Salmeterol xinafoate and fluticasone propionate aerosol can reduce the radiation incidence of the patients with local advanced NSCLC,improve patients' quality of life after radiotherapy and prevent the radiation pneumonia.
