Application of serum alpha-fetoprotein, α-L-fucosidase, 5'-nucleotidase and γ-glutamyltransferase in early diagnosis of hepatocellular carcinoma
10.3760/cma.j.issn.1006-9801.2016.08.004
- VernacularTitle:血清甲胎蛋白、α-L-岩藻糖苷酶、5'-核苷酸酶和γ-谷氨酰转肽酶在肝细胞癌早期诊断中的应用
- Author:
Haifeng GAO
;
Qiujian ZHAO
;
Jing WANG
;
Fengying GAO
;
Fen QIAO
;
Xiaoyan LI
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma;
Alpha-fetoprotein;
α-L-fucosidase;
5'-nucleotidase;
γ-glutamyltransferase
- From:
Cancer Research and Clinic
2016;28(8):519-522,527
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the application of alpha-fetoprotein (AFP),α-L-fucosidase(AFU),5'-nucleotidase(5'-NT) and γ-glutamyltransferase (GGT) in diagnosis of hepatocellular carcinoma(HCC),and to provide the basis for its early and rapid diagnosis.Methods The clinical data of 120 cases with initial diagnosis as hepatocellular carcinoma,150 cases with liver cirrhosis,200 cases with hepatitis were analyzed retrospectively from June 2013 to August 2014,meanwhile,100 healthy people were selected as control group.The serum AFP,AFU,5'-NT and GGT levels were measured by electrochemiluminescence immunoassay,rate method,peroxidase method and enzymatic colorimetric assay,respectively.The results were analyzed by receiver operating characteristic (ROC) curve,while the sensitivity,specificity,AUC were calculated at the same time.Results The levels of serum AFP,AFU,5'-NT and GGT were significantly different among HCC group,liver cirrhosis group,hepatitis group and control group (all P＜0.05).When tested alone,the sensitivities of AFP,AFU,5'-NT and GGT were 58.33 ％(70/120),82.50 ％(99/120),85.00 ％(102/120),78.33 ％(94/120),the specificities were 88.33 ％(106/120),73.33 ％(88/120),88.33 ％(106/120),71.67 ％(86/120),and AUC were 0.655,0.702,0.814,0.754.When four indexes were performed with combined test,the sensitivity was 98.33 ％(118/120),specificity was 96.67 ％(116/120),AUC was 0.975,which were higher than the single detection (all P＜0.05).Conclusion The combined detection of serum AFP,AFU,5'-NT and GGT can greatly increase the sensitivity and specificity for diagnosing HCC and will gain mutual complement advantages,which is of great clinical value for early and rapid diagnosis.
