Clinical assessment of hydrogen-rich water and oxycodone hydrochloride controlled-release tablets in the treatment of malignant neuropathic pain

VernacularTitle:富氢液联合羟考酮控释片对癌性神经病理性疼痛的临床疗效观察
Author: Dengfeng LI ; Ming YAN
Publication Type:Journal Article
Keywords: Hydrogen/AD; Oxycodone/AD; Pain,intractable/ET/DT; Neoplasms/CO/DT
From: Journal of Chinese Physician 2016;18(9):1329-1331,1335
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical efficacy of hydrogen-rich water (HRW) combined with oxycodone hydrochloride controlled-release tablets (OHCT) in the treatment of malignant neuropathic pain (MNP) patients.Methods Eighty MNP patients were randomly divided into two groups:OHCT group (group A,n =40) and HRW combined OHCT group (group B,n =40).The visual analog scale (VAS) score,frequency of pain outbreaks,pain relief rate,average dose of OHCT per day,and adverse reactions were observed.Results The VAS scores and frequency of pain outbreaks in groups A and B were significantly reduced after treatment (P ＜0.05).Compared to group A,the VAS scores,pain relief rate,outbreak pain and average dose of OHCT per day in group B were significantly improved after 14 and 28 days of treatment (P ＜ 0.05),and the adverse reactions,such as constipation,nausea and vomiting,in group B were significantly less than those in group A (P ＜ 0.05).Conclusions HRW combined with OHCT can effectively improve the MNP,and reduce average dose of OHCT per day and adverse reactions.