Experimental research about the copolymers of DR-PLGA microcapsule and CPC on the treatment of rabbit femoral defect model

VernacularTitle:骨碎补/聚乳酸-羟基乙酸共聚物微囊复合自固化磷酸钙治疗家兔股骨缺损模型的实验研究
Author: Hongzhou CHEN ; Peng WANG ; Lang WU ; Jiandong YANG
Publication Type:Journal Article
Keywords: Polypodiacease; Rhizoma-drynariae/poly,lactic-co-glycolide facid; Calcium phosphate cement; Rabbits; Treatment outcome
From: International Journal of Surgery 2016;43(5):335-338,封4
CountryChina
Language:Chinese
Abstract: Objective To study the effects about rhizoma drynariae poly (lactic-co-glycolic acid) (DR-PLGA) /Calcium phosphate cement (CPC) composite scaffold on treating rabbit femoral bone defect.Methods Eight Newzealand rabbits were randomly divided into experiment group(n =4) and control group (n =4).The preparation of rabbit femoral bone defect model,separately implanted DR-PLGA/CPC scaffold and PLGA/CPC scaffold.After 4,8 weeks,we took out the materials,observed with X-ray,gross anatomy,histology observation to evaluate the osteogenetic activity,the effect of accelerating the healing of bone defect.Resuits At the 4th week and 8th week after implantation,the effect of promoting fracture healing and osteogenic activity of the experiment group were greater than those in the control group.Conclusions DR-PLGA combined with CPC could induce new bone formation,promote the healing of rabbit femoral defect.