Effect of calcitonin combined with alfacalcidol on clinical outcome, lumbar vertebrae bone mineral density and safety in patients undergoing internal fixation of humeral shaft fracture
10.3969/j.issn.1005-1678.2016.09.019
- VernacularTitle:依降钙素联合阿法骨化醇对行内固定术肱骨干骨折患者临床效果、腰椎骨密度及安全性的影响
- Author:
Zhihua HUANG
;
Fei LIN
- Publication Type:Journal Article
- Keywords:
humeral shaft fracture;
internal fixation;
alfacalcidol;
calcitonin;
lumbar spine bone density
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(9):72-73,77
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the effect of calcitonin combined with alfacalcidol on clinical outcome,lumbar vertebrae bone mineral density and safety in patients undergoing internal fixation of humeral shaft fracture.Methods 80 patients with humeral shaft fracture treated with internal fixation in Xunwu county people's hospital from June 2010 to June 2016 were selected,and randomly divided into control group and observation group,40 cases in each groups.The control group was given calcium carbonate D3 tablets and functional exercise therapy,the observation group treated calcitonin combined with alfacalcidol on the basis of control group,analysis and comparison the clinical effects,lumbar spine BMD and safety.Results Compared with before treatment,serum calcium level of two groups increased significantly at treatment 2 weeks and 3 weeks(P<0.05);The control group BMD of lumbar spine was significantly increased in treatment 12 weeks(P<0.05),the observation group BMD of lumbar spine was significantly increased in treatment 4 weeks and 12 weeks(P<0.05).Compared with control group,the level of serum calcium in observation group was higher at treatment 2 weeks and 3 weeks (P<0.05),BMD of lumbar spine was higher at treatment 4 weeks and 12 weeks(P<0.05);The total adverse reaction rate of observation group was 10%,the difference was not statistically significant to control group 15%.Conclusion The combination of calcitonin and alfacalcidol treatment of internal fixation of humeral shaft fractures in patients with significant results, can improve serum calcium levels in patients with and improve bone mineral density, and less adverse reactions.
