Determination of Trace Platinum in Zolpidem Tartrate by GFAAS

VernacularTitle:石墨炉原子吸收光谱法测定酒石酸唑吡坦原料药中的痕量钯
Author: Liangyou QIAN ; Pingfeng ZHU ; Kaixiang ZHU ; Jia PENG ; Fangqin ZHOU
Publication Type:Journal Article
Keywords: Zolpidem tartrate; Platinum; Graphite furnace atomic absorption spectrometry
From: China Pharmacy 2016;(6):838-839,840
CountryChina
Language:Chinese
Abstract: OBJECTIVE:To establish a method for determination of trace platinum in zolpidem tartrate. METHODS:Graphite furnace atomic absorption spectrometry(GFAAS)was adopted for direct determination after dissolving sample in 1% Hydrochloric acid solution. Horizontal platform graphite tube was performed with detection wavelength of 244.79 nm,slit width of 0.2 nm and current intensity of hollow cathode lamp of 6 mA. The mode of background correction was zeeman effect,the peak height was used as measurement pattern,and the injection volume was 20 μl. RESULTS:The linear range of platinum was 0-100 ng/ml(r=0.999 0);RSDs of precision and reproducibility tests were no more than 2.0%;recovery was 97.78%-103.07%(RSD=1.6%,n=9);the detection limit was 1.48 ng/ml. CONCLUSIONS:This method is simple and rapid with good precision and accuracy,and can be applied for the determination of trace platinum in zolpidem tartrate.