Analysis of 378 Cases of Pediatric ADR Report in Our Hospital
10.6039/j.issn.1001-0408.2016.08.17
- VernacularTitle:我院378例儿童药品不良反应报告分析Δ
- Author:
Pingzhi PENG
;
Guangyi MENG
;
Jialian PANG
;
Jinquan MO
;
Haolin YAN
- Publication Type:Journal Article
- Keywords:
ADR;
Children;
Rational drug use
- From:
China Pharmacy
2016;27(8):1064-1066,1067
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the characteristics and regularity of pediatric adverse drug reactions(ADR)in our hos-pital in order to promote rational drug use of children. METHODS:In retrospective study,378 pediatric ADR cases collected from our hospital during 2010-2014 were analyzed statistically. RESULTS:Among 378 pediatric ADR cases,255 cases were male (67.46%),and 123 cases were female (32.54%);the incidence of ADR in patients aged from one year to three years were the highest (27.51%);most of the cases were induced by intravenous injection,accounting for 87.57%(331 cases);sterile powder for injection was main dosage form (236 cases,62.43%) anti-infective agents were the major cause of ADR in respect of drug types (50.26%),among which cephalothin ranked the first place(43.68%);the lesion of skin and its appendants were the most common clinical manifestation of ADR(56.35%),such as erythra and pruritus. And most of the cases were cured(64.29%)or im-proved(34.66%)after treatment. CONCLUSIONS:The occurrence of ADR are related to multiple factors,such as administration route and drug varieties. Great importance should be attached to indication,route of adiminstration,method,speed and so on,in order to promote rational drug use and reduce the occurrence of ADR.
