Analgesic Effect of Ketorolac Tromethamine Combined with Butorphanol Tartrate in the Treatment of Acute Pain after Fracture Surgery
10.6039/j.issn.1001-0408.2016.08.28
- VernacularTitle:酮咯酸氨丁三醇联合酒石酸布托啡诺用于骨折术后急性疼痛患者的镇痛效果
- Author:
Lian TANG
;
Jieying CHEN
;
Xiaobo LU
- Publication Type:Journal Article
- Keywords:
Ketorolac tromethamine;
Butorphanol tartrate;
Acute pain after fracture surgery;
Analgesic
- From:
China Pharmacy
2016;27(8):1099-1100,1101
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe analgesic effect and safety of ketorolac tromethamine combined with butorphanol tartrate in the treatment of acute pain after fracture surgery. METHODS:76 acute pain patients after fracture surgery were selected and ran-domly divided into control group and observation group,with 38 cases in each group. Control group was given Ketorolac trometh-amine injection 30 mg,ivgtt,and then 2 ml/h,0.5 mg/kg,ivgtt;observation group was additionally given butorphanol tartrate 10 mg,ivgtt,on the basis of control group. Pain degree was evaluated with VAS before and 10 min,1,2,4 and 6 h after treatment, and the occurrence of ADR was observed in 2 groups. RESULTS:10 min,1,2,4 and 6 h after treatment,VAS score of 2 groups were significantly lower than before,with statistical significance(P<0.05);6 h after treatment,VAS score of observation group was significantly higher than that of control group,with statistical significance (P<0.05);there was no statistical significance in VAS score between 2 groups 10 min,1,2 and 4 h after treatment (P>0.05). The incidence of ADR in observation group (5.26%)was significantly lower than in control group(21.05%),with statistical significance(P<0.05). CONCLUSIONS:Com-pared with ketorolac tromethamine alone,ketorolac tromethamine combined with butorphanol tartrate shows shorter analgesia dura-tion,similar therapeutic efficacy,and lower incidence of ADR.
