Clinical Observation of Nimesulide Combined with Ibuprofen in the Treatment of Pain
10.6039/j.issn.1001-0408.2016.12.11
- VernacularTitle:布洛芬联合尼美舒利治疗疼痛的临床观察
- Author:
Houping XIAO
;
Lu CAI
;
Aimin ZHANG
- Publication Type:Journal Article
- Keywords:
Ibuprofen;
Nimesulide;
Pain;
Short-term efficacy;
Safety
- From:
China Pharmacy
2016;27(12):1616-1617,1618
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the short-term efficacy and safety of nimesulide combined with ibuprofen in the treatment of pain. METHODS:84 patients with pain were randomly divided into observation group and control group. Control group was oral-ly given 0.3 g Ibuprofen sustained-release capsule,twice a day. Observation group was additionally given 100 mg Nimesulide cap-sule,twice a day. The treatment course for both groups was 7 d. Clinical efficacy,visual analogue (VAS) score,quality of life (QOL) score,coagulation indexes (prothrombin time,thrombin time,fibrinogen,activated partial thromboplastin time) before and after treatment,and incidence of adverse reactions in 2 groups were observed. RESULTS:The total effective rate in observa-tion group was significantly higher than control group,the differences were statistically significant(P<0.05). Before treatment, there were no significant differences in the VAS score and QOL score between 2 groups(P>0.05). After treatment,VAS scores in 2 groups were significantly lower than before,and observation group was lower than control group,QOL scores were significantly higher than before,and observation group was higher than control group,the differences were statistically significant(P<0.05). And there were no significant differences in the coagulation indexes and incidence of adverse reactions between 2 groups(P>0.05). CONCLUSIONS:The short-term efficacy of ibuprofen combined with nimesulide is superior to ibuprofen alone in the treatment of pain,with similar short-term safety.
