Preparation and Dissolution Rate in vitro of Idebenone Solid Dispersion
10.6039/j.issn.1001-0408.2015.34.26
- VernacularTitle:艾地苯醌固体分散体的制备及体外溶出度研究Δ
- Author:
Rong HU
;
Shuangxi CHEN
;
Haijun ZHONG
;
Hua YU
;
Rong LUO
;
Zeyuan DENG
- Publication Type:Journal Article
- Keywords:
Idebenone;
Solid dispersion;
Poloxamer 407;
Dissolution rate
- From:
China Pharmacy
2015;(34):4831-4833,4834
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare Idebenone solid dispersion,and to investigate its dissolution rate in vitro. METHODS:Us-ing Poloxamer 407(P407)as carrier,the influence of preparation methods(solvent method,melting method)and the ratio of the drug to P407(1∶1,1∶3,1∶8)on the dissolution of drug were investigated by single factor design. The state of idebenone in ma-trix of solid dispersion was further determined by using differential scanning calorimetry (DSC) and X-ray powder diffraction (XRD). RESULTS:Idebenone solid dispersion prepared by solvent method(the ratio of the drug to poloxamer was 1∶3)showed dissolution rate of 80%. The majority of idebenone existed in the solid dispersion at amorphous forms or molecular state. CONCLU-SIONS:Idebenone solid dispersions with high dissolution rate in vitro is prepared successfully.