Clinical Observation of Montelukast Sodium Assistant Treatment for Syncytial Virus Bronchiolitis
10.6039/j.issn.1001-0408.2015.32.36
- VernacularTitle:孟鲁司特钠辅助治疗合胞病毒毛细支气管炎的临床观察
- Author:
Jinqing CHEN
- Publication Type:Journal Article
- Keywords:
Respiratory syncytial virus;
Bronchiolitis;
Montelukast sodium;
Therapeutic efficacy;
Safety
- From:
China Pharmacy
2015;(32):4565-4566,4567
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe therapeutic efficacy and safety of montelukast sodium assistant treatment for respiratory syncytial virus(RSV)bronchiolitis. METHODS:76 RSV bronchiolitis neonatus were included in this study and randomly divided into control group(37 cases)and observation group(39 cases). Control group was treated with regular treatment,oxygen inhala-tion,sedation,abatement of fever,cough suppression,eliminating phlegm,Budesonide suspension,aerosol inhalation of Albuter-ol solution;observation group was additionally given montelukast 4 mg,qd,on the basis of control group. The clinical efficacy, cough,suffocative and wheezing rale disappearance time,length of stay were compared between 2 groups. The serum level of Cys-teinyl leukotrienes (CysLTs) before and after treatment and ADR were also compared between 2 groups. RESULTS:After treat-ment,total clinical efficacy of observation group(94.87%)was significantly higher than that of control group(78.38%),with sta-tistical significance(P<0.05);the time of couth,suffocative,wheezing rale disappearance and length of stay in observation group were significantly shorter than those of control group,with statistical significance (P<0.05);after treatment,the serum level of CysLTs in 2 groups were both significantly lower than before,the observation group was lower than the control group,with statisti-cal significance(P<0.05). No obvious ADR was found in 2 group during treatment. CONCLUSIONS:Montelukast sodium assis-tant treatment for RSV bronchiolitis is effective with less ADR.
