Trends of Antipsychotic Drugs Use in Schizophrenia Patients from Hebei Province
10.6039/j.issn.1001-0408.2015.32.02
- VernacularTitle:河北省精神分裂症患者抗精神病药使用变化趋势调查
- Author:
Ping ZHANG
;
Keqing LI
;
Hailing JIA
;
Yunshu ZHANG
;
Xiuli SUN
;
Jianfeng LI
;
Baoping YAN
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Cross-sectional study;
Antipsychotic drug;
Trend analysis;
Drug combination treatment
- From:
China Pharmacy
2015;(32):4468-4470,4471
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To provide reference for rational use of antipsychotic drugs in schizophrenia patients. METHODS:The general information and antipsychotic treatment information,which were extracted from the database of prior drug investigation in Mental Health Center of Hebei Province in 2002,2006 and investigation data in 2012 of 5014 schizophrenia patients,were ana-lyzed. RESULTS:Over time,the frequency of the first generation antipsychotic drugs decreased(P<0.05),while that of the sec-ond generation antipsychotic drugs increased (P<0.01). The frequency of long-acting antipsychotic drugs were generally low among outpatients and inpatients in 2002,2006,2012,with statistical significance(P<0.01). There were no significant difference in the proportion of outpatients receiving antipsychotic drugs combination treatment and monotherapy (P>0.05). Over time,the proportion of inpatients receiving monotherapy decreased,while that of inpatients receiving combination treatment increased (χ2=18.682,P<0.01). CONCLUSIONS:The second generation antipsychotic drugs have gradually replaced the first generation antipsy-chotic drugs,and have became the leading drugs in the treatment of schizophrenia in Hebei province. The proportion of inpatients receiving combination treatment has increased,which is different from the domestic and foreign prevention and treatment guide-lines.
