Clinical Observation of Xiaoer Jiegan Granules with Ribavirin in the Treatment of Acute Upper Respiratory Tract Infection
10.6039/j.issn.1001-0408.2015.32.40
- VernacularTitle:小儿解感颗粒联合利巴韦林治疗急性上呼吸道感染的临床观察
- Author:
Hongxia FANG
;
Kewei SHEN
- Publication Type:Journal Article
- Keywords:
Xiaoer jiegan granule;
Ribavirin;
Acute upper respiratory tract infection;
Clinical effect analysis
- From:
China Pharmacy
2015;(32):4575-4576,4577
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe therapeutic efficacy and safety of Xiaoer jiegan granules with Ribavirin in the treatment of acute upper respiratory tract infection. METHODS:98 patients with upper respiratory tract infection were randomly divided into obser-vation group and control group with 49 cases in each group. Control group was given Ribavirin injection for routine upper respiratory tract antiviral therapy,10-15 mg/kg,added into 5% Glucose injection 250 ml,ivgtt,qd. Observation group was given Xiaoer jiegan granules,1g/time for 1-3 year-old children,2g/time for 4-6 year-old children and 3 g/time for 7-9 year-old,tid. A treatment course of 2 groups lasted for 5 days,both received 2 courses of treatment. Clinical efficacy,cough and other symptoms score,ADR were ob-served in 2 groups. RESULTS:The effective rate of observation group (97.96%) was higher than that of control group (87.76%), with statistical significance(P<0.05). Before treatment,there was no significant difference in the scores of fever and cough and other symptoms between 2 groups,with statistical significance(P>0.05);after treatment, the scores of fever and cough and other symp-toms in observation group were lower than in control group,with statistical significance(P<0.05). The incidence of ADR in the ob-servation group(6.12%)was significantly lower than in control group(22.45%),with statistical significance(P<0.05). CONCLU-SIONS:Xiaoer jiegan granule with Ribavirin is effective in the treatment of acute upper respiratory tract virus infection,and can im-prove fever,cough and other clinical symptoms,so as to promote better conditions and reduce the occurrence of ADR.
