Effect of Ulinastatin on Related Parameters of Patients Successful Cardiopulmonary Resuscitation after Car-diac Arrest but Concurrent Post-resuscitation Syndrome
10.6039/j.issn.1001-0408.2015.30.11
- VernacularTitle:乌司他丁对心搏骤停后经心肺复苏成功但并发复苏后综合征患者相关指标的影响
- Author:
Xiang LU
- Publication Type:Journal Article
- Keywords:
Cardiac arrest;
Cardiopulmonary resuscitation;
Ulinastatin;
Post-resuscitation
- From:
China Pharmacy
2015;(30):4208-4209,4210
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the effect of ulinastatin on related parameters of patients with successful cardiopulmonary resuscitation (CRP) after cardiac arrest but concurrent post-resuscitation syndrome (PRS). METHODS:76 patients with successful CRP after cardiac arrest and PRS were randomly divided into test group and control group. Control group was given conventional treatment;test group was additionally given ulinastatin 200 000 U adding into 0.9% Sodium chloride injection 20 ml by intrave-nous injection,every 12 h. The treatment course was 7 d for 2 groups. The myocardial enzyme parameters (m-AST,HDBH and CK-MB)in ROSC immediately,24 h,48 h and 72 h,renal function parameters(Cr,BUN);predictors of disease(ALB and Lac) and incidence of adverse reactions and survival rate in 2 groups were observed. RESULTS:All above-mentioned parameters in 2 groups showed flutuations in ROSC immediately,and test group was better than control group,the differences were statistically sig-nificant(P<0.05);patients with adverse reactions in test group were significantly less than control group,survival rate was signifi-cantly higher than control group,the differences were statistically significant(P<0.05). CONCLUSIONS:Ulinastatin can effective-ly control the inflammatory response factor of PRS patients,improve parameters of critical illness and survival rate.
