Clinical Observation of Formoterol Combined with Budesonide in the Treatment of Chronic Bronchial Asth-ma
10.6039/j.issn.1001-0408.2015.30.07
- VernacularTitle:福莫特罗联合布地奈德治疗慢性支气管哮喘的临床观察
- Author:
Kai ZHU
- Publication Type:Journal Article
- Keywords:
Aerosol inhalation;
Formoterol;
Budesonide;
Chronic bronchial asthma;
Efficacy;
Safety
- From:
China Pharmacy
2015;(30):4198-4199,4200
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the efficacy and safety of formoterol combined with budesonide in the treatment of chron-ic bronchial asthma. METHODS:Totally 80 patients with chronic asthmatic patients were randomly divided into control group and test group. Control group was given corticosteroids,antibacterial drugs or doxofylline and other conventional treatment;based on the treatment of control group,test group was treated with formoterol 1 suck+budesonide 1 suck by aerosol inhalation,once-twice a day. The treatment course was 2 weeks. The clinic data was observed,including clinical efficacy,IL-17,IL-33,FEV1/FVC,PEF before and after treatment,daytime symptom scores,nighttime symptom scores and incidence of adverse reactions. RESULTS:The total effective rate in test group was significantly higher than control group,the difference was statistically significant(P<0.05). Af-ter treatment,IL-17,IL-33,daytime symptom scores and nighttime symptom scores in 2 groups were significantly lower than be-fore,and test group was lower than control group,FEV1/FVC and PEF were significantly higher than before,and test group was higher than control group,the differences were statistically significant(P<0.05 or P<0.01). There was no significant difference in the total incidence of adverse reactions(P>0.05). CONCLUSIONS:Based on the conventional treatment,formoterol combined with budesonide has good efficacy and safety in the treatment of chronic bronchial asthma.
