Systematic Review of the Effect of Danhong Injection on Hemorheology in Patients with Angina Pectoris in Coronary Heart Disease
10.6039/j.issn.1001-0408.2015.27.21
- VernacularTitle:丹红注射液对冠心病心绞痛患者血液流变学影响的系统评价
- Author:
Sha LI
;
Fang WANG
;
Lan MA
;
Chan LIANG
;
Sunxin CHEN
;
Guiyang LIU
- Publication Type:Journal Article
- Keywords:
Danhong injection;
Coronary heart disease;
Angina pectoris;
Hemorhelogy;
Meta-analysis
- From:
China Pharmacy
2015;(30):4236-4238,4239
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To systematically review the effect of Danhong injection on hemorhelogy in patients with angina pec-toris in coronary heart disease(CHD),and provide evidence-based reference for clinical treatment. METHODS:Retrieved from PubMed,EMBase,Medline,Cochrane Library,CJFD,VIP database,Wanfang database,and retrieved relevant literatures manual-ly,the randomized controlled trials (RCT) about the effect of Danhong injection on hemorhelogy in patients with angina pectoris in CHD were collected. After the quality evaluation and information collection of clinical studies with inclusion criteria,Meta-analy-sis was conducted by using Rev Man 5.2 software. RESULTS:A total of 12 RCT were enrolled,involving 1 160 patients. Results of Meta-analysis showed the conventional treatment of Danhong injection could more effectively improve the high blood viscosity [MD=-0.87,95%CI(-1.24,-0.50),P<0.001],low blood viscosity[MD=-2.43,95%CI(-3.99,-0.87),P=0.002],hemato-crit value[MD=-0.05,95%CI(-0.10,-0.00),P=0.04],plasma viscosity[MD=-0.58,95%CI(-0.78,-0.38),P<0.001] and fibrinogen level[MD=-1.06,95%CI(-1.65,-0.47),P<0.001],compared with convertional treatment,there were significant dif-ferences. CONCLUSIONS:Based on the conventional treatment,Danhong injection has improvement effect on the related indica-tors of hemorhelogy in patients with angina pectoris in CHD. Due to the limit of methodological quality and sample size,it remains to be further verified with more rigorously designed and long-term follow-up of large-scale RCT.
