Simultaneous Determination of Camphor and Menthol in Compound Diphenhydramine Liniment by GC
10.6039/j.issn.1001-0408.2015.30.43
- VernacularTitle:GC法同时测定复方苯海拉明搽剂中樟脑和薄荷脑的含量
- Author:
Linhong GOU
;
Baowen AN
;
Junli WANG
;
Xi LIU
- Publication Type:Journal Article
- Keywords:
GC;
Compound diphenhydramine liniment;
Camphor;
Menthol;
Content determination
- From:
China Pharmacy
2015;(30):4297-4298,4299
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish a method for simultaneous determination of camphor and menthol in Compound diphen-hydramine liniment. METHODS:GC was performed on the column of Agilent 19095N-123 INNOWAX capillary column,column temperature was 120 ℃,injection volume temperature was 220 ℃,FID detector was used with the temperature of 260 ℃,carrier gas was nitrogen gas,flow of column was 6.0 ml/min,air was 450 ml/min,hydrogen gas was 40 ml/min,split ratio was 20∶1 and injection volume was 1 μl. RESULTS:The linear range of mass concentration was 0.612-6.12 mg/ml(r=0.999 9)for camphor and 0.593-5.93 mg/ml(r=0.999 9)for menthol;RSDs of precision,stability and reproducibility tests were lower than 2%;the recov-eries were respectively 98.0%-100.7%(RSD=1.0%,n=6)and 98.7%-100.7%(RSD=0.7%,n=6). CONCLUSIONS:The meth-od is simple,accurate and reproducible,and can be used for the contents determination of camphor and menthol in Compound di-phenhydramine liniment.
