Protective Effects of Baimai Ointment on Sciatic Nerve Injury in Rabbit Model
10.6039/j.issn.1001-0408.2016.19.21
- VernacularTitle:白脉软膏对家兔坐骨神经损伤的保护作用
- Author:
Jie LU
;
Wanqiang ZHANG
;
Weipeng YANG
;
Jian ZHANG
;
Fuyin LI
- Publication Type:Journal Article
- Keywords:
Baimai ointment;
Sciatic nerve injury;
Behavior;
Pathology;
NOS;
NMDA;
Rabbit
- From:
China Pharmacy
2016;27(19):2657-2659,2660
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the protective effects of Baimai ointment on sciatic nerve injury in rabbit. METHODS:The rabbit sciatic nerve injury model was induced by forceps operation. 180 rabbits were randomly divided into 6 groups,with 30 rab-bits in each group (10 rabbits of 7,14,28 d),including sham operation group (blank matrix of Baimai ointment for external use),model group(same as sham operation group),positive group [ig Mecobalamine tablet solution 1.25×10-4 g/(kg·d)] and Bai-mai low-dose,medium-dose and high-dose groups [Baimai ointment 0.33,0.67 and 1.34 g/(kg·d)for external use],once a day, for consecutive 7,14 and 28 d. Gait instrument was used to test the foot-touch-land force of rabbit;pathology examination was conducted for sciatic nerve resection;immunohistochemistry was used to detect the levels of NOS and NMDA in nerve tissue. RE-SULTS:Baimai ointment can significantly relieve sciatic nerve injury,edema and inflammatory reaction;7,14 and 28 d after med-ication,compared with model group,foot-touch-land force decreased significantly in rabbits with sciatic nerve injury (P<0.01);14,28 d after medication,foot-touch-land force of rabbits increased significantly in positive group,Baimai ointment groups,while the levels of NOS and NMDA decreased in nervous tissue(P<0.05). CONCLUSIONS:Baimai ointment can protect sciatic nerve with function injury in rabbits.
