Optimization of Ethanol Mixed-extraction Technology of Red ginseng and Salvia miltiorrhiza in Xinlikang Granules by Multiple Indexes Comprehensive Evaluation Method Combined with Orthogonal Test
10.6039/j.issn.1001-0408.2016.19.27
- VernacularTitle:多指标综合评分法结合正交试验优化心力康颗粒中红参与丹参的混合醇提工艺Δ
- Author:
Shaochen WANG
;
Yujie GUO
;
Ye REN
;
Hongjin WU
;
Jianxun LIU
- Publication Type:Journal Article
- Keywords:
Xinlikang granules;
Red ginseng;
Salvia miltiorrhiza;
Ginsenoside;
Tanshinone ⅡA;
Salvianolic acid B;
Multiple indexes comprehensive evaluation;
Orthogonal test
- From:
China Pharmacy
2016;27(19):2678-2680,2681
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To optimize the ethanol mixed-extraction technology of Red ginseng and Salvia miltiorrhiza in Xin-likang granules. METHODS:L9(34)orthogonal test was adopted to optimize ethanol mixed-extraction technology with ethanol vol-ume fraction,amount of ethanol and extraction times as factors using weighting coefficient comprehensive score of the contents of ginsenoside Rg1,Re and Rb1 in R. ginseng and the contents of tanshinone ⅡA and salvianolic acid B in S. miltiorrhiza as index;and the verification test was detected. RESULTS:Optimal mixed-ethanol extraction technology was as follows as 6-fold 70% etha-nol,reflux extracting for 3 times,2 h each time. In verification test,average contents of ginsenosides Rg1,Re,Rb1 in R. ginseng and those of tanshinone ⅡA and salvianolic acid B in S. miltiorrhiza were 3.963 8,0.757 3,4.986 2,0.964 7,27.662 5 mg/g,re-spectively,and comprehensive score was 0.96 (RSD=1.26%,n=3). CONCLUSIONS:Ethanol extraction technology of R. gin-seng and S. miltiorrhiza in Xinlikang granules optimized by multiple indexes comprehensive score combined with orthogonal test is stable,reasonable and feasible.
