Effects of Ginkgo biloba Extract on Proliferation and Apoptosis of Gastric Cancer Cell Line SGC7901
10.6039/j.issn.1001-0408.2015.25.19
- VernacularTitle:银杏叶提取物对胃癌SGC7901细胞增殖与凋亡的影响
- Author:
Haiting CHEN
;
Jiangbiao HU
;
Minpan LU
- Publication Type:Journal Article
- Keywords:
Ginkgo biloba extract;
Gastric cancer cell line SGC7901;
Proliferation;
Apoptosis
- From:
China Pharmacy
2015;(25):3510-3511,3512
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effects of Ginkgo biloba extract (GBE) on proliferation and apoptosis of gastric cancer cell line SGC7901. METHODS:After the cells were cultured in 0,5,10,20,50,100 and 200 μg/ml GBE for 48 h,cell viability was determined by MTT method and inhibition rate was calculated. After the cells were cultured in 0,10,50 and 200μg/ml GBE for 48 h,flow cytometry was used to detect cell cycle distribution and the apoptosis rate. RESULTS:Following 48 h culture of cells in 5,10,20,50,100 and 200μg/ml GBE,the growth of cells were obviously inhibited in a dose-dependent man-ner. After 48 h culture of cells in 10,50 and 200 μg/ml GBE,the apoptosis rate was increased. CONCLUSIONS:GBE can inhibi-tion the proliferation of SGC7901,and induces it apoptosis,the former dominated.
