Clinical Observation of Guizhi Fuling Capsule Combined with Tamoxifen Citrate Tablet in the Treatment of Breast Hyperplasia
10.6039/j.issn.1001-0408.2015.24.13
- VernacularTitle:桂枝茯苓胶囊联合枸橼酸他莫昔芬片治疗乳腺增生的临床观察
- Author:
Xiyan ZHANG
- Publication Type:Journal Article
- Keywords:
Guizhi fuling capsule;
Tamoxifen citrate tablet;
Breast hyperplasia;
Efficacy;
Safety
- From:
China Pharmacy
2015;(24):3345-3346,3347
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the clinical efficacy and safety of Guizhi fuling capsule combined with Tamoxifen citrate tablet in the treatment of breast hyperplasia. METHODS:216 female patients with breast hyperplasia were randomly divided into control group and observation group. Control group was orally treated with Tamoxifen citrate tablet 10 mg,bid. Observation group was additionally orally treated with Guizhi fuling capsule 3 granules,tid. The treatment course was 3 months. Drug withdrawal was conducted in menstrual period. The clinic data was observed,including clinical efficacy,the maximum mass diameter and breast pain scores before and after treatment,and incidence of adverse reactions. RESULTS:The total effective rate in observation group was significantly higher than control group,the difference was statistically significant(P<0.05). After treatment,the maximum mass diameter and breast pain scores in 2 groups were significantly lower than before,and observation group was lower than con-trol group,the difference was statistically significant(P<0.05). There was no significant difference in the incidence of adverse reac-tions(P>0.05). CONCLUSIONS:Guizhi fuling capsule combined with Tamoxifen citrate tablet has more significant efficacy than only Tamoxifen citrate tablet in the treatment of breast hyperplasia,with similar safety.
