Clinical Observation of Low Molecular Heparin in the Treatment of Cancer-associated Acute Pulmonary Thromboembolism
10.6039/j.issn.1001-0408.2015.24.15
- VernacularTitle:低分子肝素治疗癌症相关性急性肺血栓栓塞症的临床观察
- Author:
Guangqiang WEI
;
Bolin SUN
- Publication Type:Journal Article
- Keywords:
Warfarin;
Low molecular heparin;
Cancer-associated acute pulmonary thromboembolism;
Efficacy;
Safety
- From:
China Pharmacy
2015;(24):3349-3350,3351
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the clinical efficacy and safety of low molecular heparin in the treatment of cancer-associ-ated acute pulmonary thromboembolism(APTE). METHODS:42 patients with cancer-associated APTE were randomly divided into combination group and simple drug group. All patients were given anti-cancer conventional treatment. Based on it,simple drug group was treated with Low molecular heparin injection 0.1 ml/kg by subcutaneous injection after embolism,q12 h;based on the treatment in simple drug group,combination group was additionally treated with Warfarin sodium tablet initial dose was 3 mg after 1-3 d of treatment,orally,qd. The dosage of warfarin was adjusted based on the international normalized ratio(INR),when INR was 2-3 for continuous 2 days,low molecular heparin was stopped,only warfarin was orally gave. The treatment course was 3 months. The clinic data was observed,including clinical efficacy,and pulmonary arterial blood gas indexes [blood oxygen pressure (pO2)and blood carbon dioxide partial pressure(pCO2)] before and after treatment. The fatality rate,re-embolism rate and bleed-ing rate in 6 months were followed-up,and the incidence of adverse reactions was recorded. RESULTS:The total effective rate in simple drug group was significantly higher than combination group,re-embolism and fatality rate were significantly lower than com-bination group,the differences were statistically significant(P<0.05). After treatment,the pulmonary arterial blood gas indexes in 2 groups were significantly higher than before and simple drug group,the differences were statistically significant(P<0.05). There were no significant differences in the bleeding rate and incidence of adverse reactions between 2 groups(P>0.05). CONCLU-SIONS:Based on conventional treatment,the low molecular heparin has better efficacy than sequential therapy in the treatment of APTE,with similar safety.
