Efficacy and Safety of Modified Infusion versus Traditional Infusion of Meropenem in the Treatment of Se-vere Infectious:a Meta-analysis
10.6039/j.issn.1001-0408.2015.24.25
- VernacularTitle:美罗培南改良输注方式对比传统输注方式治疗严重感染疗效和安全性的Meta分析
- Author:
Yubo XIAO
;
Rongling LI
;
Lili WU
;
Bingzheng SHEN
;
Lu ZHANG
- Publication Type:Journal Article
- Keywords:
Meropenem;
Modified infusion;
Meta-analysis;
Efficacy;
Safety
- From:
China Pharmacy
2015;(24):3378-3381,3382
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To systematically evaluate the efficacy and safety of modified infusion(2-4 h infusion or continuous 24 h infusion)versus traditional infusion(0.5-1 h infusion)of meropenem in the treatment of severe infectious,and to provide evi-dence-based reference for clinic treatment. METHODS:Retrieved from Medline,CJFD,VIP database and Wanfang database, modified infusion(test group)versus traditional infusion(control group)of meropenem in the treatment of severe infections were collected,and Mata-analysis was performed by using Rev Man 5.0 statistical software after extracting data and evaluating quality. RESULTS:A total of 13 studies were included,involving 1 012 patients. Results of Meta-analysis showed the effective rate [RR=1.25,95%CI(1.10,1.43),P<0.001] and bacterial eradication rate [RR=1.25,95%CI(1.05,1.48),P=0.01] in test groups were sig-nificantly higher than those of control group,and there were no significant differences in the mortality rate [RR=0.74,95%CI (0.46,1.18),P=0.21] and incidence of adverse reactions [RR=0.81,95%CI(0.48,1.39),P=0.45]. CONCLUSIONS:Compared with traditional infusion of meropenem,extended or continuous infusion can improve efficacy in the treatment of severe infections, with similar safety. Due to methodology limit of included studies,large-scale and high quality RCT are required for further valida-tion of the conclusions.
