Literature Analysis of 27 Cases of Adverse Drug Reactions Induced by Compound Glycyrrhiza Mixture/Oral Solution
10.6039/j.issn.1001-0408.2015.24.19
- VernacularTitle:复方甘草合剂/口服溶液致不良反应27例文献分析
- Author:
Lei ZHANG
- Publication Type:Journal Article
- Keywords:
Compound glycyrrhiza mixture/oral solution;
Adverse drug reaction;
Literature analysis
- From:
China Pharmacy
2015;(24):3361-3362,3363
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the general regularity and characteristics of adverse drug reactions (ADR) induced by Compound glycyrrhiza mixture/oral solution,and provide reference for clinical ration use of drug. METHODS:The literatures of ADR induced by Compound glycyrrhiza mixture/oral solution were retrieved in CJFD and Wanfang database from 1995 to 2014, and the collected 27 cases of ADR were classified,summarized and statistically analyzed. RESULTS:The 27 cases of ADR were more common in middle-aged and aged patients(18 cases,66.66%);all patients were orally administrated,and 9 of them had rel-atively larger dose;there were 12 cases with combination medication;the proportion of the incidence of ADR within 30 min and af-ter 1 d was similar,it was 29.63%;involved organs/systems were mainly skin and its appendages(27.59%),circulatory system damage (24.14%),nervous system damage (19.54%) and systemic damage (14.94%);26 patients were recoveried after drug withdrawal and treatment,one patient died. CONCLUSIONS:The incidence of ADR of Compound glycyrrhiza mixture/oral solu-tion should be reduced by actively carrying out medication propaganda and education,carefully asking patients before treatment, strictly select medication groups and methods and strengthening medication monitoring and warning,etc.
