Effect of Organic Cation Transporter 2(808G>T)Gene Polymorphism on Metformin Hydrochloride Phar-macokinetics in vivo of Health Volunteer:a Meta-analysis
10.6039/j.issn.1001-0408.2015.24.27
- VernacularTitle:有机阳离子转运体2（808G＞T）基因多态性对健康受试者体内盐酸二甲双胍药动学影响的Meta分析
- Author:
Jia SONG
;
Yubo WU
;
Lilong LIU
;
Yumeng WU
;
Tingting ZHANG
;
Yexin WANG
- Publication Type:Journal Article
- Keywords:
Diabetes;
Metformin;
Gene polymorphism;
Organic cation transporter 2
- From:
China Pharmacy
2015;(24):3386-3388,3389
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To systematically review the effect of organic cation transporter 2 [(OCT2)808G>T] gene polymor-phism on the metformin hydrochloride pharmacokinetics in vivo,and to provide evidence-based reference for clinical medication. METHODS:Retrieved from PubMed,EMBase,Foreign Medical Journey Service,CJFD,VIP database and Wanfang database,re-lated studies about the effect of (OCT2)808G>T gene polymorphism on the metformin hydrochloride pharmacokinetics in vivo were collected,and Meta-analysis was performed by using Rev Man 5.1 statistics software. RESULTS:A total of 5 retrospective studies were included,involving 172 patients. The result of gene type was type GT,type TT and type GG. Results of Meta-analysis showed,compared with type GT volunteers,type TT could prolong the half-time period of metformin hydrochloride;compared with type TT,type GG could increase the peak concentration. However,(OCT2)808G>T gene polymorphism had no effects on the renal clearance rate,creatinine clearance rate and area under the drug-time curve. CONCLUSIONS:(OCT2)808G>T gene poly-morphism has certain effect on the half-time period and peak concentration of metformin hydrochloride in vivo of health volunteer, and has no effect on the renal clearance rate,creatinine clearance rate and area under the drug-time curve. Due to the limit of re-search methodological quality,large-scale and high quality studies are required for further validation of the conclusions.
