Study on the Relationship between the Perioperative Application of Antibiotics in Caesarean Operation and Neonatal Hyperbilirubinemia
10.6039/j.issn.1001-0408.2015.23.36
- VernacularTitle:剖宫产围术期使用抗菌药物与新生儿高胆红素血症的关系研究
- Author:
Xiaomei WU
;
Wenbin LI
- Publication Type:Journal Article
- Keywords:
Equivalent dose;
Antibiotics;
Perioperative period;
Cesarean section
- From:
China Pharmacy
2015;(23):3273-3274,3275
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the relationship between the perioperative application of antibiotics in caesarean opera-tion and neonatal hyperbilirubinemia,and to provide reference for reducing the incidence of neonatal hyperbilirubinemia. METH-ODS:264 cases of cesarean section women were randomly divided into control group and observation group,with 132 cases in each group. Control group was given antibiotics after operation,and observation group was given prophylactic application of antibi-otics before operation,and equivalent dose of intravenous injection after operation. Postoperative maximum and average tempera-ture,white blood cell(WBC),neutrophils(NEUT),complications and economic index were compared between 2 groups after op-eration. RESULTS:There was no statistically significant difference in postoperative maximum and average temperature,WBC count,NEUT proportion,wound infection and fever rate between 2 groups (P>0.05). The costs of medication,drug dosage per capita,hospital stay and the incidence of neonatal hyperbilirubinemia in observation group were significantly lower than in control group,with statistical significance (P<0.05). CONCLUSIONS:The perioperative standard use of antibiotics in caesarean opera-tion could effectively reduce the incidence of postoperative neonatal hyperbilirubinemia and hospitalization cost,and cut down treat-ment time. It also has a high economic value and worthy of promotion.
