Systematic Review of the Efficacy and Safety of Prostaglandin E1 Combined with Hydration for the Preven-tion of Contrast-induced Nephropathy
10.6039/j.issn.1001-0408.2015.18.25
- VernacularTitle:前列腺素E1联合水化预防造影剂肾病疗效和安全性的系统评价
- Author:
Lei ZHANG
;
Yanhong WEI
;
Liping MA
;
Sijing SHEN
- Publication Type:Journal Article
- Keywords:
Prostaglandin E1;
Prevention;
Contrast-induced nephropathy;
Systematic review;
Meta-analysis
- From:
China Pharmacy
2015;(18):2521-2523,2524
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To systematically evaluate the efficacy and safety of prostaglandin E1 combined with hydration for the prevention of contrast-induced nephropathy(CIN)and provide evidence-based reference for the clinical treatment. METHODS:The PubMed,Medline (Ovid),EMbase (Ovid),Cochrane Library,VIP,CJFD and WanFang database were retrieved to collect the randomized controlled trails(RCT)of prostaglandin E1 combined with hydration for the prevention of CIN. After information collec-tion and methodology quality evaluation,the Meta-analysis was performed using Rev Man 5.3 software. RESULTS:12 RCTs involv-ing 1 732 patients were included. The results of Meta-analysis showed that the incidence of CIN in test group was significantly low-er than control group[RR=0.40,95%CI(0.30,0.53),P<0.001],the incidence of phlebitis was higher than control group [RR=10.18,95%CI(1.37,75.67),P=0.02] and there was no significant difference in the need rate of renal replacement between test group and control group[RR=0.44,95%CI(0.12,1.61),P=0.21]. CONCLUSIONS:Intravenous prostaglandin E1 combined with hydration can effectively reduce the incidence of CIN. Occurance of phlebitis should be paid attention to. Due to the limited quality and sample of included studies,it remains to be further verified by high-quality and large-sample RCT.
