Clinical Observation of Azithromycin Combined with Reduning Injection in the Treatment of Children with Mycoplasma Pneumoniae Infection
10.6039/j.issn.1001-0408.2015.18.06
- VernacularTitle:阿奇霉素联合热毒宁注射液治疗肺炎支原体感染患儿的临床观察
- Author:
Hua WAN
;
Chunhua LI
;
Nian ZHAO
;
Qin OU
- Publication Type:Journal Article
- Keywords:
Mycoplasma pneumoniae infection;
Azithromycin;
Reduning injection;
Efficacy;
Safety
- From:
China Pharmacy
2015;(18):2468-2469,2470
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the clinical efficacy and safety of azithromycin combined with Reduning injection in the treatment of children with mycoplasma pneumoniae infection. METHODS:80 children with mycoplasma pneumoniae infection were randomly divided into control group and research group. All the children were given routine treatment,including oxygen inha-lation,defervescence,nutritional support,reducing sputum and relieving asthma,etc. Based on it,children in control group were orally treated by Azithromycin enteric coated tablets 10 mg/kg,once a day. Children in research group were treated by Reduning in-jection 10 ml and 5% glucose injection 100 ml by intravenous infusion,once a day,based on the treatment in control group. The course of both was 14 d. The clinical data was observed,including the clinical efficacy,interleukin-6 (IL-6),interleukin-8 (IL-8),tumor necrosis factor-α(TNF-α)and the incidence of adverse reactions(ADR)before and after treatment. RESULTS:The total effective rate in research group was significantly higher than control group,with significant difference(P<0.05). After treat-ment,the IL-6,IL-8 and TNF-α in 2 groups were significantly lower than before,and research group was lower than control group,with significant difference(P<0.05). There were no significant differences in the incidence of ADR in 2 groups(P>0.05). CONCLUSIONS:Based on the routine treatment,azithromycin combined with Reduning injection has more obvious efficacy than only azithromycin in the treatment of children with mycoplasma pneumoniae infection with similar safety.
