Clinical Observation of Candesartan Combined with Amlodipine Besylate in the Treatment of Elderly Hyper-tension
10.6039/j.issn.1001-0408.2015.21.12
- VernacularTitle:坎地沙坦联合苯磺酸氨氯地平治疗老年高血压的临床观察
- Author:
Shengmin GUO
- Publication Type:Journal Article
- Keywords:
Candesartan;
Amlodipine besylate;
Elderly hypertension;
Efficacy;
Safety
- From:
China Pharmacy
2015;(21):2911-2912,2913
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the clinical efficacy and safety of candesartan combined with amlodipine besylate in the treatment of elderly hypertension. METHODS:Totally 156 elderly patients with hypertension were randomly divided into control group and observation group. Patients in control group were orally given Amlodipine besylate tablets 5 mg in the morning,once a day. Patients in observation group were orally given Candesartan tablets 8 mg based on the treatment of control group,once a day. The course of both was 8 weeks. The clinical data was observed,including clinical efficacy,systolic blood pressure(SBP)and dia-stolic blood pressure(DBP)before and after treatment,fasting blood glucose(FPG),insulin resistance index(HOMA-IR),24 h urinary albumin total(mAlb),serum creatinine(SCr)and the incidence of adverse reactions. RESULTS:The total effective rate in observation group was significantly higher than control group;the HOMA-IR,mAlb and SCr in observation group were significant-ly lower than control group,with significant difference(P<0.05). After treatment,the blood pressure in 2 groups was significantly lower than before,and observation group was lower than control group,with significant differences(P<0.05);there was no sig-nificant difference in the FPG(P>0.05). There were no obvious adverse reactions during treatment. CONCLUSIONS:Candesartan combined with amlodipine besylate has better efficacy than only amlodipine besylate in the treatment of elderly hypertension,with similar safety.
