Effect of Fluvastatin on Serum vWF and D-D Levels and Heart Function of Patients with Chronic Heart Failure
10.6039/j.issn.1001-0408.2015.21.17
- VernacularTitle:氟伐他汀对慢性心力衰竭患者血浆假性血友病因子、D-二聚体及心功能的影响
- Author:
Debiao LIU
;
Hui YANG
- Publication Type:Journal Article
- Keywords:
Fluvastatin;
Chronic heart failure;
Plasma von willebrand factor;
D-dimer;
Heart function
- From:
China Pharmacy
2015;(21):2925-2926,2927
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To study the effect of fluvastatin on plasma von willebrand factor (vWF),D-dimer(D-D)level and heart function in patients with chronic heart failure(CHF). METHODS: 78 patients with CHF were randomly divided into control group and test group. Control group was given conventional treatment,including cardiac glycoside drugs,diuretics,angiotensin converting enzyme inhibitors or angiotensin receptor blockers andβ-receptor blockers,etc. On this basis,test group was given Fluv-astatin capsules 40 mg,administrated at draught after dinner. The course for both was 28 d. The clinic data was observed,includ-ing left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),vWF,D-D levels before and after treatment and incidence of adverse reactions. RESULTS:After treatment,the LVEF level in 2 groups was significantly higher than before,and test group was higher than control group;LVEDD,vWF and D-D level were significantly lower than before,and test group was lower than control group,with significant differences(P<0.05). There were no obvious adverse reactions during treat-ment. CONCLUSIONS: Based on the conventional treatment,fluvastatin can significantly improve the coagulation function in pa-tients with CHF,with good safety.
