Clinical efficacy of amiodarone combined with botulinum toxin A in hemifacial spasm
10.3969/j.issn.1005-1678.2016.08.031
- VernacularTitle:胺碘酮联合肉毒素A治疗面肌痉挛的临床疗效观察
- Author:
Jianqin FENG
;
Pengfei ZHANG
- Publication Type:Journal Article
- Keywords:
hemifacial spasm;
amiodarone;
botulinum toxin A;
Cohen rating
- From:
Chinese Journal of Biochemical Pharmaceutics
2016;36(8):113-115,118
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy of amiodarone combined with botulinum toxin A in the treatment of hemifacial spasm.Methods Sixty-five patients with hemifacial spasm were randomly divided into amiodarone(n=33)and control(n=32)group.In the amiodarone group,oral amiodarone and local intramuscular injection of botulinum toxin A were administered.In the control group,only local intramuscular injections of botulinum toxin A was performed.The clinical efficacy was evaluated according to the Cohen rating on the 1st,4th,16th,32nd week.Results The Cohen rating in amiodarone group was significantly better than control group on 4th,16th,32nd week(P<0.05).The complete remission in amiodarone group was significantly higher than control group on 4th,16th,32nd week(75.8% vs.43.8%,81.8% vs.12.5%,81.8% vs.6.2%,all P <0.05).The total effective rate in amiodarone group was significantly higher than control group on 16th,32nd week(97.0%vs.75.0%,93.9% vs.65.6%,all P<0.05). There was one case of recurrence in control group on 4th week,while there was no recurrence in amiodarone group.The recurrence in control group on 16th,32nd week was higher than amiodarone group(56.3 % vs.0.0 %,65.6% vs.12.1%,all P<0.05).There was no signigicant difference in adverse reactions between amiodarone group and control group(24.2%vs.18.8%).Conclusion Combination of amiodarone and botulinum toxin A is more effective than botulinum toxin A alone in the treatment of hemifacial spasm.
