Research of multidrug resistance mechanisms of neuroblastoma
10.3760/cma.j.issn.1673-4408.2016.10.003
- VernacularTitle:神经母细胞瘤多药耐药机制的研究
- Author:
Xue LI
- Publication Type:Journal Article
- Keywords:
Neuroblastoma;
Resistance mechanism
- From:
International Journal of Pediatrics
2016;43(10):748-753,759
- CountryChina
- Language:Chinese
-
Abstract:
Neuroblastoma(NB) is the most common extracranial solid malignant tumor in childhood,which has various clinical manifestations.Tumor metastasis or relapse is one of the major causes of death in patients with NB.At present,the treatments of NB are mainly concentrated on the surgery,chemotherapy,radiation therapy,myeloablative therapy and transplantation,tumor targeted therapy,etc.But the treatment of children with high-risk NB is still not optimistic.Studies have shown that multidmg resistance is a major impediment to the successful treatment of NB.Hence,it is of great significance to have a comprehensive understanding of the chemoresistance mechanisms to improve the survival rate of NB patients.This review discusses the chemoresistance mechanisms of NB in several respects.
