Expression of Monocyte Chemotactic Protein-1 and Its Receptor in Sudden Coro-nary Death

VernacularTitle:单核细胞趋化蛋白1及其受体在冠心病猝死中的表达
Author: Yuanyuan KUANG ; Xiaxia CHEN ; Cangcheng WANG ; Kun YE ; Ying WANG ; Yonghua SHI
Publication Type:Journal Article
Keywords: forensic pathology; death,sudden,cardiac; m onocyte chem otactic protein-1; C C chem okine protein receptor-2
From: Journal of Forensic Medicine 2014;(6):413-415,418
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of m onocyte chem otactic protein-1 (MCP-1) and its receptor CCchem okine receptor-2 (CCR-2) in coronary atherosclerosis plaques betw een sudden coro-nary death (SCD ) and non-SCD. Methods The expression levels of MCP-1 and CCR-2 in SCD group, coronary atherosclerosis group (non-SCD), control group (norm al coronary artery) w ere detected by im-m unohistochem istry. Results Positive rates of MCP-1 am ong the three groups w ere 78%, 47%, and 0%, respectively, w ith significant expressing differences betw een each tw o groups (P<0.05). Positive rates of CCR-2 am ong three groups w ere 72%, 47%, and 0%, respectively, w ith significant expressing differ-ences betw een the SCD group and coronary atherosclerosis group as w ell as betw een the SCD group and control group (P<0.05), but w ith no significant expressing difference betw een coronary atherosclero-sis group and control group (P>0.05). Conclusion O verexpression of MCP-1 and CCR-2 in coronary atherosclerotic plaques is closely correlated w ith SCD .